I think it will make a huge difference. Personally, I never understand why defederation is frowned upon. There are some instances that are just so toxic that they don’t deserve to be heard.
For the record, I’m a bit of a political extremist myself being an anarchist, but the users that I dislike are people who dunk on you without even giving you a chance, and political opinions that excuse things like authoritarianism and genocide. There’s a lot of that on hexbear, lemmygrad, and even .ml