robertroy, a science en
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ameliajeff, a science en

A Cosmic Odyssey - The NU Trilogy Begins

In the infinite expanse of the universe, on the precipice of the Milky Way, humanity embarked on a journey of boundless ambition. The dawn of interstellar colonization was heralded by the construction of the Voyager III, within the newly established HG Rickover Shipyard, nestled in the asteroid belt.

As the colossal construction of the Voyager III took its fledgling steps into the abyss, there was an unfolding cosmic drama, unbeknownst to the inhabitants of Earth. In the celestial realms of Orion, a group of visitors emerged, crossing the galactic threshold from the Andromeda Galaxy into the Milky Way, their origins steeped in an ancient, unfathomable conflict spanning billions of years.

At the heart of this unfolding saga was Sted Richardson, an individual who had ardently aspired to lead the very first interstellar mission. He had endeavored to etch his name into the annals of history as the one who would lead humanity to the stars. However, the fates took a cruel turn when an unforeseen mishap, a freak accident on Tranquility Base located on Earth's moon, Luna, shattered his dreams. The accident left him bereft of both legs, amputated above the knees, shattering his eligibility to captain that pioneering mission.

In the shadow of despair, a glimmer of hope emerged - advanced prosthetic legs, a technological marvel of the future, offered a chance for redemption. It was with these mechanical limbs that Sted Richardson would embark on an unexpected journey, one that would catapult him into a new and uncharted destiny.

As the captain of a state-of-the-art mining assay ship, Sted found himself thrust into the forefront of a cosmic battle, a battle for the very survival of humanity itself. The stage was set, the characters aligned, and the destiny of Earth intertwined with forces that transcended space and time.

"Nu Book 1: A Cosmic Odyssey - The NU Trilogy Begins" is a mesmerizing entry into a riveting narrative that explores the audacious spirit of human exploration and the unforeseen encounters with powers and races that have traversed galaxies, setting the stage for an epic trilogy that will unravel the mysteries of the universe itself.

ameliajeff, a science en

THE U.S.S. ENVIRONMENT: Remnant of Humanity's Hope

In the year 2061, President Andrea Larsen, freshly inaugurated, is confronted with a chilling revelation - a recently discovered asteroid hurtling toward Earth, destined to strike in December 2068, bringing the looming threat of mass extinction. Amidst this apocalyptic shadow, President Larsen's maternal instincts kick in, igniting a daring quest to ensure the survival of her very young adopted son, Hayden. Her resolve triggers a complex political endeavor, one that sets the wheels in motion for the grandest of undertakings: the construction of a spaceship, the U.S.S. Environment, designed to carry Hayden and a select crew of diverse, promising young individuals on a journey to a distant, habitable exoplanet, a staggering 4.2 trillion light-years away.

But with the fate of humanity hanging in the balance, questions loom large. Who will earn their place on this vessel of salvation? How will the selection process unfold, and can a ship of such monumental scale and complexity be constructed in the midst of the turbulence and upheaval that defines the tumultuous era of the 2060s?

A brutal truth underscores this grand endeavor - Earth stands as the solitary haven in our solar system, blessed with the life-sustaining essentials of water and oxygen. It is this scarcity that compels President Larsen to cast her sights on the Alpha Centauri system, a destination that lies 50 years away by even the most advanced propulsion system of the 2060s. But the challenges extend beyond distance; they encompass the essentials for survival.

The crew must contend with the riddles of longevity: 50 years of oxygen, food, water, and electricity. This narrative unravels the ingenious solutions to these perplexing questions. It illuminates the means by which an audacious endeavor such as settling an exoplanet becomes more than just a dream; it is transformed into a tangible, awe-inspiring reality.

"THE U.S.S. ENVIRONMENT: Remnant" isn't just a speculative tale of survival; it's an exploration of human ingenuity, resilience, and the unwavering spirit of hope that burns brightly, even in the darkest corners of the cosmos. As we delve into this narrative, we bear witness to the audacious efforts to secure a future for humanity amidst the stars, revealing a testament to human potential and the pursuit of a dream so colossal it stretches across the fabric of time and space.

ameliajeff, a science en

Embark on an extraordinary adventure of self-discovery, courage, and uncertainty with "The Habesha Princess: Discovery." In this groundbreaking fantasy novel, witness the awe-inspiring journey of an African princess in a land before time as she battles against fierce mythic creatures that command the lands of Habesha and nefarious sorcerers and alchemists who wield dark magic.

This is a thrilling journey with a brave and determined protagonist as she overcomes challenging obstacles, uncovers hidden truths, and confronts formidable adversaries. Her perilous adventures will leave you spellbound and eager to discover what happens next.

But "The Habesha Princess: Discovery" is more than just an exhilarating adventure—it is a tale of friendship, loyalty, and the enduring power of the human spirit. As our hero discovers her true potential, she forges alliances with captivating characters who will become your beloved companions. Together, they navigate treacherous paths, overcoming obstacles with bravery and resilience, teaching us profound lessons about courage and discovery.

"The Habesha Princess: Discovery" weaves an enchanting tapestry of culture, mythology, and destiny. Transport yourself to the rich landscapes of Habesha land, Africa, where sprawling savannahs, lush rainforests, and majestic kingdoms await your exploration. As you delve into an unforgettable tale, prepare to be captivated by the sights, sounds, and flavors of this extraordinary continent’s oldest inhabitants, the Habesha People.

Don't miss this opportunity to be a part of a literary milestone. Grab your copy of "The Habesha Princess: Discovery: Book 1" and let its pages transport you to a world of magic, heritage, and boundless imagination. Witness the birth of a new era in fantasy literature—one that celebrates diversity, embraces cultural pride, and leaves an indelible mark on your soul. Join Princess Selam on her extraordinary journey today and be part of a tale that will inspire generations to come.

ameliajeff, a science en

Embark on an extraordinary adventure of self-discovery, courage, and uncertainty with "The Habesha Princess: Discovery." In this groundbreaking fantasy novel, witness the awe-inspiring journey of an African princess in a land before time as she battles against fierce mythic creatures that command the lands of Habesha and nefarious sorcerers and alchemists who wield dark magic.

This is a thrilling journey with a brave and determined protagonist as she overcomes challenging obstacles, uncovers hidden truths, and confronts formidable adversaries. Her perilous adventures will leave you spellbound and eager to discover what happens next.

But "The Habesha Princess: Discovery" is more than just an exhilarating adventure—it is a tale of friendship, loyalty, and the enduring power of the human spirit. As our hero discovers her true potential, she forges alliances with captivating characters who will become your beloved companions. Together, they navigate treacherous paths, overcoming obstacles with bravery and resilience, teaching us profound lessons about courage and discovery.

"The Habesha Princess: Discovery" weaves an enchanting tapestry of culture, mythology, and destiny. Transport yourself to the rich landscapes of Habesha land, Africa, where sprawling savannahs, lush rainforests, and majestic kingdoms await your exploration. As you delve into an unforgettable tale, prepare to be captivated by the sights, sounds, and flavors of this extraordinary continent’s oldest inhabitants, the Habesha People.

Don't miss this opportunity to be a part of a literary milestone. Grab your copy of "The Habesha Princess: Discovery: Book 1" and let its pages transport you to a world of magic, heritage, and boundless imagination. Witness the birth of a new era in fantasy literature—one that celebrates diversity, embraces cultural pride, and leaves an indelible mark on your soul. Join Princess Selam on her extraordinary journey today and be part of a tale that will inspire generations to come.

mihair, a science en
@mihair@kbin.social avatar
breadandcircuses, a random en

Although we've mentioned this before, it's grim news that bears repeating. Global heating caused by human industry is melting glaciers and sea ice all around the world — but nowhere more dramatically than on and near Antarctica.


Sea ice that covers the ocean around Antarctica hit a record low surface area in the winter, a preliminary analysis of US satellite data shows, and scientists fear the impact of climate change is increasing at the southern pole.

“This is the lowest sea ice maximum in the 1979 to 2023 sea ice record by a wide margin,” said the NSIDC, a government-supported programme at the University of Colorado at Boulder.

At one point this year, sea ice had dropped to 1.03 million sq km, far smaller than the previous record low and an area of loss roughly the size of Texas and California combined.

“It’s a record-smashing sea ice low in the Antarctic,” NSIDC scientist Walt Meier said in comments published by NASA.


The excerpt above is from a news story published at Al Jazeera.

FULL STORY -- https://www.aljazeera.com/news/2023/9/26/antarctic-sea-ice-hits-record-smashing-low-coverage-area-new-data-show

Over at Medium, an article by Ricky Lanusse goes into more depth on the subject, and concludes with this heartfelt lament...


It’s been 33 years since the first IPCC report on climate change. Three-plus decades of climate negotiations and disappointment: emissions soaring, climate denial, on-paper optimism, and ‘net zero, but not in my term’ speeches.

Now, the northern summer of 2023 is officially the hottest on record, pushing global sea temperatures to record highs and disrupting ocean ecosystems. Over 3.8 billion people — almost half the world — felt the wrath of human-induced extreme heat between June and August.

You don’t grab buckets or towels when your bathtub overflows, ignoring or denying the problem. You turn off the tap. Climate change isn’t a future problem; it’s here. And you might think it won’t affect you, but as temperatures climb, more will face such dire choices. The question is not if but when.

Antarctica’s struggle isn’t a far-off concern; it’s a glaring reminder that climate change is here and spares no place on Earth.


FULL ARTICLE -- https://archive.ph/9sNKh#selection-2503.0-2503.132

mihair, a science en
@mihair@kbin.social avatar

Stevia is considered a "natural non-caloric sweetener." Saccharin and sucralose are considered "non-nutritive sweeteners" (few or no calories). Aspartame is a "nutritive sweetener" (adds some calories but far less than sugar).
Aspartame comes with a warning to be used cautiously (or not at all) by people with a rare genetic disease (called phenylketonuria, or PKU) because they have trouble metabolizing it; that's not true for the other sweeteners. And all four vary on their level of sweetness and aftertaste, which is likely why people often prefer one over another.

https://www.health.harvard.edu/blog/sweeteners-time-to-rethink-your-choices-2019022215967

mihair, a science en
@mihair@kbin.social avatar

With a low to no calorie sugar count, artificial sweeteners may seem like a treat for people with diabetes. But recent research indicates that artificial sweeteners may actually be counterintuitive, especially if you’re looking to manage or prevent diabetes.
In fact, the increased consumption of these sugar substitutes may correlate to the increase of obesity and diabetes cases.

https://www.healthline.com/health/type-2-diabetes/diabetes-stevia#overview

mihair, a science en
@mihair@kbin.social avatar

Stevia is an ideal replacement for traditional sugar, especially if you have diabetes or a carbohydrate-controlled diet. That way, you can enjoy sweet foods without dealing with diabetic complications. Unlike normal sugar made of sucrose, stevia contains stevioside. It is a glycoside compound, not a carbohydrate. Table sugar is absorbed into the bloodstream. As stevioside breaks down, the glucose is absorbed in the colon by bacteria.

https://facty.com/food/nutrition/10-surprising-benefits-and-risks-of-the-alternative-sweetener-stevia/?style=quick&utm_source=adwords&adid=267723668343&ad_group_id=57749014289&utm_medium=c-search&utm_term=stevia&utm_campaign=FH-USA-Search-Health-Benefits-and-Risks-of-Stevia&gclid=EAIaIQobChMI1v_2gJqCgQMV1gQGAB1JAgLjEAAYAyAAEgL1VvD_BwE

mihair, a science en
@mihair@kbin.social avatar

Pancreatic cancer has an extremely poor prognosis, largely due to a poor record for early detection. Known risk factors for pancreatic cancer include obesity, diet, and diabetes, implicating glucose consumption and regulation as a key player. The role of artificial sweeteners may therefore be pertinent to disease kinetics. The oncogenic impact of artificial sweeteners is a highly controversial area.
https://www.frontiersin.org/articles/10.3389/fonc.2017.00018/full

mihair, a science en
@mihair@kbin.social avatar

Stevia, a zero-calorie sugar substitute, is recognized as safe by the Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). In vitro and in vivo studies showed that stevia has antiglycemic action and antioxidant effects in adipose tissue and the vascular wall, reduces blood pressure levels and hepatic steatosis, stabilizes the atherosclerotic plaque, and ameliorates liver and kidney damage. The metabolism of steviol glycosides is dependent upon gut microbiota, which breaks down glycosides into steviol that can be absorbed by the host. In this review, we elucidated the effects of stevia’s consumption on the host’s gut microbiota.
https://www.mdpi.com/2076-2607/10/4/744/htm

mihair, a science en
@mihair@kbin.social avatar

To help offset potential stevia induced gut challenges, support your gut flora with fiber and prebiotics like FOS10 (fructo-oligosaccharides). Increase your intake of beneficial bacteria Lactobacillus and Bifidus to aid in a healthier gut microbiome.
Consider foods and nutrients like cruciferous vegetables (Brussels sprouts, cabbage, broccoli, cauliflower, kale), silymarin, dandelion, resveratrol, curcumin, magnesium, zinc, limonene, B vitamins, and omega-3 oils to help your liver’s glucuronidation pathway.

https://www.bbc.com/mundo/noticias/2013/07/130717_salud_nutricion_stevia_finde_gtg

mihair, a science en
@mihair@kbin.social avatar

Ancestral intake of the raw stevia leaf was extremely limited compared to current exposures of refined stevia found in many manufactured food products. I am a proponent of using foods in their natural, whole form when possible.
Avoid processed refined sugars and foods with added sugars, but rather use raw local honey, blackstrap molasses, real maple syrup, or other natural sugars. Think about it, would your grandmother or great grandmother use something like refined stevia in their made from scratch homemade recipes?

https://medlineplus.gov/spanish/druginfo/natural/682.html

mihair, a science en
@mihair@kbin.social avatar

Artificial sweeteners or intense sweeteners are sugar substitutes that are used as an alternative to table sugar. They are many times sweeter than natural sugar and as they contain no calories, they may be used to control weight and obesity. Extensive scientific research has demonstrated the safety of the six low-calorie sweeteners currently approved for use in foods in the U.S. and Europe (stevia, acesulfame-K, aspartame, neotame, saccharin and sucralose), if taken in acceptable quantities daily. There is some ongoing debate over whether artificial sweetener usage poses a health threat .This review article aims to cover thehealth benefits, and risks, of consuming artificial sweeteners, and discusses natural sweeteners which can be used as alternatives.

https://pubmed.ncbi.nlm.nih.gov/25842566/

mihair, a science en
@mihair@kbin.social avatar

Stevia rebaudiana Bertoni is a perennial shrub with zero calorie content that has been increasing in popularity for its potential use as an adjuvant in the treatment of obesity. The level of evidence supporting general benefits to human health is insufficient. We conducted a review of the literature summarizing the current knowledge and role in human disease.
A growing body of evidence indicates that Stevia rebaudiana Bertoni is protective against malignant conversion by inhibition of DNA replication in human cancer cell growth in vitro.

https://pubmed.ncbi.nlm.nih.gov/29995279/

madalinai, a science en
@madalinai@kbin.social avatar

Some research papers conclude that stevia consumption can cause cancer due to DNA breakage and chromosome mutations. However, none of those studies are based on human subjects.
According to a study published in Oncotarget in 2018, steviol significantly limited the growth of human gastrointestinal cancer cells.

https://www.bekarmic.com/blogs/knowledge-base/stevia-and-cancer-everything-about-stevia

madalinai, a science en
@madalinai@kbin.social avatar

The use of steviol glycosides as non-caloric sweeteners has proven to be beneficial for patients with type 2 diabetes mellitus (T2D), obesity, and metabolic syndrome. However, recent data demonstrate that steviol and stevioside might act as glucocorticoid receptor (GR) agonists and thus correlate with adverse effects on metabolism. Herein, we evaluated the impact of steviol, steviol glycosides, and a Greek-derived stevia extract on a number of key steps of GR signaling cascade in peripheral blood mononuclear cells (PBMCs) and in Jurkat leukemia cells.
https://pubmed.ncbi.nlm.nih.gov/28754349/

madalinai, a science en
@madalinai@kbin.social avatar

Prostate cancer is the second most harmful disease in men worldwide and the number of cases is increasing. Therefore, new natural agents with anticancer potential should be examined and the response of existing therapeutic drugs must be enhanced. Stevia pilosa and Stevia eupatoria are two species that have been widely used in traditional medicine, but their effectiveness on cancer cells and their interaction with antineoplastic drugs have not been studied. The results indicate that SPME and SEME have an inhibitory effect on the viability and migration of prostate cancer cells and do not interfere with the enzalutamide anticancer effect. The data suggest that Stevia extracts may be a potential source of molecules for cancer treatment.

https://pubmed.ncbi.nlm.nih.gov/32102219/

madalinai, a science en
@madalinai@kbin.social avatar

Steviol glycosides are currently being used as natural sweeteners by the food industry and Stevia rebaudiana has long been used as a sweet plant in South America for patients suffering from diabetes. In this study, a Stevia rebaudiana ethanolic extract (SREE) was prepared, analysed and tested for antioxidant activity in terms of free radical scavenging properties and antiproliferative effects in cervix (HeLa), pancreatic (MiaPaCa-2) and colonic (HCT116) cancer cells. The antiproliferative mechanism was confirmed by testing the effects on cyclin D1-CDK4.
https://pubmed.ncbi.nlm.nih.gov/27071804/

madalinai, a science en
@madalinai@kbin.social avatar

Hydroponics offers a viable solution for obtaining plant products that are rich in micronutrients and ultramicronutrients, such as selenium. Selenium plays a crucial role in strengthening the body's immune defense and acts as a potent antioxidant. Low levels of selenium have been associated with an increased risk of heart attacks, strokes, and cancer. Stevia rebaudiana Bertoni (SrB), a relatively new crop in plant cultivation, was the focus of the present study. SrB has numerous medicinal and prophylactic properties, and its leaves are rich in macro- and microelements, vitamins, and diterpene glycosides.

https://pubmed.ncbi.nlm.nih.gov/37522778/

madalinai, a science en
@madalinai@kbin.social avatar

Stevia is unaffected by stomach acid, pancreatic enzymes and the process of digestion. It travels essentially “untouched” by the digestive process until it reaches the large intestine. There it “reacts” with the gut flora. It is then absorbed in the colon and travels to the liver. It is then bound to glucuronic acid via the glucuronidation pathway and eventually excreted through the urine. The glucuronidation pathway is a major liver pathway that detoxifies drugs, pollutants, estrogen, and steroids, etc.

https://www.portalsalud.com/cuales-son-los-peligros-de-la-stevia_13092860/

madalinai, a science en
@madalinai@kbin.social avatar

Bladder cancer (BC) is a global health issue that lacks effective treatment strategies. Growing evidence suggests that various natural products possess anti-tumour effects. This study aims to identify a novel agent that can be used in the treatment of BC.
Collectively, our data suggest that stevioside can be a potential agent for the treatment of BC.

https://pubmed.ncbi.nlm.nih.gov/35820501/

mihair, a science en
@mihair@kbin.social avatar

Gustul ceaiului de kombucha diferă de la un producător la altul în funcție de metodele de preparare. Tocmai de aceea vă invităm să testați cele 8 sortimente iKombucha. După o experiență de peste 7 ani în producerea de kombucha, am adăugat la rețetele noastre stevia ca și îndulcitor, pentru ca produsul final să nu fie prea acru la gust pentru majoritatea clienților. Am dezvoltat 8 sortimente cu diferite arome, care să acopere înr-o anumită măsură gustul de ferment și să ofere gusturi plăcute.

https://healthfully.com/stevia-and-cancer-5918164.html

mihair, a science en
@mihair@kbin.social avatar

Stevioside is a diterpene glycoside found in the leaf of Stevia rebaudiana, a traditional oriental medicinal herb, which has been shown to have various biological and ethno-medicinal activities including antitumor activity. In this study, we investigated the effects of stevioside on the cytotoxicity, induction of apoptosis, and the putative pathways of its action in human breast cancer cells (MCF-7). For the analysis of apoptotic pathway, measurement of reactive oxygen species (ROS) and assessment of mitochondrial transmembrane potential (MTP) were achieved. We showed that stevioside was a potent inducer of apoptosis and it conveyed the apoptotic signal via intracellular ROS generation; thereby inducing change in MTP and induction of mitochondrial mediated apoptotic pathway. Taken together, our data indicated that stevioside induces the ROS-mediated mitochondrial permeability transition and results in the increased expression of apoptotic proteins such as Bax, Bcl-2 and Caspase-9. Effect of stevioside on stress-related transcription factors like NF-E2-related factor-2 opens up a new vista for further studies. This is the first report on the mechanism of the antibreast cancer (in vitro) activity of stevioside.

https://pubmed.ncbi.nlm.nih.gov/23061910/

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